Halothane

Question: Halothane? How does the halothane affect the motor neuron or motor synapse and its physiology? Thank you!

Answer: Halothane's effects on neuromuscular blockade appear to be central in origin, although there may be some activity on the postjunctional membrane. Here is an abstract of an article that sought to explain halothane's effect on neurons: http://www.jneurosci.org/cgi/content/abs… And another: http://jp.physoc.org/cgi/content/abstrac… That one is succinct. Although I don't use halothane anymore, I can tell you that clinically, it potentiates neuromuscular blockade, but doesn't provide enough depression of motor function to eliminate the need for neuromuscular blocking drugs. Hope that helps.

Question: HALOTHANE??????????? what effects could halothane have on motor neuron, motor synapse, or the physiology of muscle contraction? please help

Answer: Halothane is a potent general anaesthetic administered by inhalation, used for inducing and maintaining anaesthesia in all types of surgical operations. However, it may cause liver damage and is less widely used now than formerly.

Question: euthanizing rats with Halothane or Isoflurane and then feeind to a snake? I am looking at more humanely killing my snake food rather than let the snake strike it and strangle it, I was going to attempt euthanizing it. I was planning on using Halothane or Isoflurane to put the rat to sleep. After which I would feed the ball python the snake right after it passed away. Would using either of the chemicals and then immediately feeding or freezing the rodent have an ill effect on the health of the ball python?

Answer: Any chemical in the rat will go into the snake. Commercial rat suppliers usually use CO2 ( or so I've heard, but CO2 death is not usually considered to be all that "pleasant" either) Truly painless...carbon monoxide, and that shouldn't hurt the snake. My snakes are pretty efficient. It's all over in a matter of seconds. A traditional "instant" method of killing small rodents is to put a finger on either side of the neck and snap the tail hard, thus breaking the neck, or to put them in a bag and whack them very hard on a hard surface. That is how many zoos and care facilities do it.

Question: Why would Halothane cause a patient to twitch? I'm doing a case study for my Physiology class and in it a person is put under the anesthesia Halothane. Shortly after the patient goes under he begins twitching, and his heart rate increases. I'm a bit stumped as to what exactly is the cause of this twitching (an allergy to Halothane perhaps?). Any help is appreciated, thanks!

Answer: That's not an allergy. Are you sure the patient didn't also get succinylcholine? That causes muscle fasciculations. I've never personally seen a case of malignant hyperthermia, but you might consider that in your differential diagnosis. It would certainly cause tachycardia, as well as in increase in end-tidal carbon dioxide. There is muscle rigidity and breakdown, so twitching might also occur. (We don't use Halothane anymore. It has been replaced by Sevoflurane. Halothane had a nasty habit of causing arrhythmias by sensitizing the heart to catecholamines. I saw a lot of junctional rhythms and aberrant conduction when we used it.)

Question: Where can you buy halothane a medicine for pets? So when trimming the does nails she can be restful and calm.

Answer: Halothane is an inhalant anesthetic, so unless you have an anesthetic machine with oxygen in your house, AND you have a prescription from a veterinarian for the halothane, I don't think you can get it.

Question: Is there anywhere in Louisiana where I can buy Halothane? My rat needs to be euthanized and using halothane seems to be the most humane and painless way to euthanize rats at home.

Answer: Halothane and other similar anesthetics are not available to the public.

Question: How do succinylcholine and halothane trigger malignant hyperthermia in person with Ryanodine receptor mutation? As title

Answer: Through tissue/cellular infusion, resulting in overproduction of procaine and the inability to metabolize niacin and vitamin D. . MWAP

Question: What does halothane do to your body? Does it relax all your muscles so you can't use them?, So you can't move at all and are completely numb for a well depending on how much you inhale? Any information about this would be helpful, I tried researching it myself, but it was hard to understand. I under stand it's and anesthesia but whats that?

Answer: Halothane vapour is an inhalational general anaesthetic. A general anaesthetic drug is an anaesthetic drug that brings about a reversible loss of consciousness. These drugs are generally administered by an anaesthesia provider in order to induce or maintain general anaesthesia to facilitate surgery. In addition to controlling pain and making you unconscious, general anesthesia control the body's reaction to stress and relieves fear and anxiety associated with surgery. Halothane was given to many millions of adult and pediatric patients worldwide from its introduction in 1956 through the 1980s. Its properties include cardiac depression at high levels, cardiac sensitisation to catecholamines such as norepinephrine, and potent bronchial relaxation. Its lack of airway irritation made it a common inhalation induction agent in pediatric anaesthesia. Due to its cardiac depressive effect, it was contraindicated in patients with cardiac failure. http://www.stjohn.org/HealthInfoLib/swAr… http://en.wikipedia.org/wiki/Halothane

Question: What effect could halothane have on the motor neuron, motor synapse or the physiology of muscle contraction?

Answer: Strange. I asked this question here awhile ago and I got this answer: http://answers.yahoo.com/question/index;… I'm not sure if we're from the same class...

Question: What are other uses for halothane other than general anethesia?

Answer: Halothane, 2-Bromo-2-chloro-1,1,1-trifluoroethane (structure F3C-CHBrCl), is listed in the Merck Index, 13th Ed, as an anesthetic for both human and veterinary purposes. It is in some ways analagous to some of the refrigerants (Freons), but I don't find it listed for that purpose in the CRC. Here's a wikipedia reference for more info: http://en.wikipedia.org/wiki/Halothane

Question: using halothane for euthanasia on ratties? i've read that this is the most humane inhalation gas. i have been unfortunate in the past with my pet rats all having to suffer to long or suffering at the hands of inexpereanced vets cause our regular vet was not available. so can anyone tell me for home euthanaisia if & where i could purchase halothane in australia melbourne in particular.

Answer: using halothane to kill an animal is relatively hard. it'll put them to sleep real good, but inevitably once you think they're dead and you remove the inhalational agent, they'll start gradually waking up. it only makes sense if you're going to anesthetize the animals with the halothane and then REALLY kill them with a more reliable method (decapitation or intravenous injection of potassium for instance)

Question: What is the critical temperature of Halothane?

Answer: 50.2 degrees Celsius

Question: What to do with leftover Halothane? My friend's mother was a veterinarian, and passed away several weeks ago. She was also the owner and sole practitioner of her practice. My friend inherited everything, including the hospital and all of it's supplies and equipment. Among things to get rid of include several boxes of liquid HALOTHANE gas. How do we get rid of it? Can we give it to another veterinarian? Or does the DEA have to be be involved? I know it's not legal to just flush it down the toilet. Thanks!

Answer: You need to contact the proper authorities about disposing of it.

Question: How does Halothane function? Is it in the synaptic cleft and binds to acetylcholinesterase? Does it bind to the muscle membrane and act as Acetycholine allowing a continual stream of Calcium? Does it bind to the muscle membrane and block Acetylcholine resulting in a period of tetanus and then fatigue? HELP! I have no more ideas

Answer: All great possibilities! In addition, you might add an effect on the lipid bilayer of neurons, interrupting impulse transmission. Unfortunately, the exact mechanism of action of this class of anesthetics isn't known, even after almost two centuries of use.

Question: what is the molar mass of halothane? halothane has a density of 6.74 g/L at 65 degrees celsius and 720 torr. What is the molar mass of halothane? I know that 720 torr is .947 atm & 65 degrees celsius is 338 K how can I use this to solve the problem

Answer: PV = nRT ====> (n/V) = P/RT (n/V) = mol/L, but you have been given g/L; the conversion involves the molar mass (MM): g/L = (g/mol)(mol/L) ===> 6.74 g/L = MM x (n/V) or MM = 6.74 g/L x (V/n) = 6.74 g/L x (V/n) = 6.74 g/L x (RT/P) MM = 6.74 g/L x (0.0821 L-atm/mol*K)(338 K)/0.947 atm MM = 197.55 g/mol

Question: what effects could halothane have on motor neuron, motor synapse or the physiology of musle contraction?

Answer: Halothane is an anesthetic gas used in surgery. It is really no longer used (as of the 1980's) as it was associated with liver damage. The mechanism of action with respect to these compounds like halothane, isoflurane, ect. is not completely understood, but it appears to affect GABA receptors, and inhibits potassium channel conduction. It reduces pain sensitivity (probably through the action of GABA, glycine and glutamate receptors) and relaxes muscles (skeletal muscles) most likely through the potassium channel mechanism.

Question: i am a medical treacher i saw a picture in google images on halothane anaesthesia 3000 bc pls explain percep? e anaethesia in need an explanation on this

Answer: WTF?

Question: Chemistry problem: A halothane- oxygen mixture (C2HBrCLF3 + O2) can be used as an anesthetic....? ... A tank containing such a mixture has the following partial pressures: P(halothane)= 170 mmHg and P(O2)= 570 mmHg. a) What is the ratio of the number of moles of halothane to the number of moles of oxygen? b) If the tank contains 160g of O2, what mass of C2HBrClF3 is present?

Answer: 170 / 570 =0.298 = ratio halothane / O2 moles O2 = 160 / 32 = 5 0.298 x 5 = 1.49 moles halohane multilpy by the molar mass

Question: what is the maximum recommended dose of adrenaline that can be used on a patient taking halothane anaesthesia? i am referring to a generally fit patient taking halothane and for some reason ( reduce bleeding, post op pain relief, augment pain relief) the surgeon also wants to use a local anaesthetic containing adrenaline.

Answer: You would want to try to avoid adrenaline when giving halothane as halothane sensitizes the heart to the effects of catecholamines and can cause dysrhythmias. Change gases an follow ACLS protocol

Question: one more question about halothane? do you know how halothane directly depresses the sinoatrial node of the heart and therefore heart rate/rhythm?

Answer: Halothane sensitizes the heart to catecholamines, increasing the chance of arrhythmias. When we used it, clinically we'd see a LOT of junctional rhythms and extrasystoles. It was almost unusual to see a normal P wave. Thank God for sevoflurane!