A common local anesthetic
Question: What would Carboxylic acid have to combine with to make lidocaine? Also;
What reaction would these two compounds undergo in order to form lidocaine?
What is the other product of this reaction?
If one of the compounds was carboxylic acid what would the other compound need to be?
Answer: 1) 2,6,-dimethylaniline and 1-chloroacetic acid combine to form lidocaine.
2) Condensation Reaction
Question: How safe is it to use pure lidocaine powder? I would like to mix some with a cream as a pain relife for my back. The msds sheet that came with it makes me scared to even open it. Is it safe? If i mix 1 gram of lidocaine with 9 grams of cream does that give me a 10% Concentration?
Answer: In the proper concentrations, it may be safe enough to use, but I would do some more extensive research into it to find the appropriate dose to be on the safe side.
Wiki says it does help topically with itching, burning, and pain from skin inflammation, but it does have several contraindications:
* Heart block, second or third degree (without pacemaker)
* Severe sinoatrial block (without pacemaker)
* Serious adverse drug reaction to lidocaine or amide local anaesthetics
* Concurrent treatment with quinidine, flecainide, disopyramide, procainamide (Class I antiarrhythmic agents)
* Prior use of Amiodarone hydrochloride
* Hypotension not due to Arrhythmia
* Accelerated idioventricular rhythm
Needless to say, I'd be rather careful when dealing with something like this. I would also note that there's a long list under drug interactions below that on Wiki, too.
Yes, if you mix 1 gram of Lidocaine into 9 grams of cream, it would be 10% Lidocaine... but you'd also want to make sure it was mixed really, really well so there aren't any globs of Lidocaine that might cause irritation (or worse). Good luck!
Question: Has anyone used lidocaine to numb the skin before a tattoo? so my husband's friend was just tellin us how when he got his chest tatted up his artist used lidocaine to numb the area, and his peice turned out awesome. well we so happen to have a bottle of lidocaine from our last visit to the hospital. has anyone ever used it for this purpose? what was the end result of your tattoo??
i have plenty of tattoos. i know what it feels like. and its not crazy. some shops sell skin numbing agents in their shops for more sensitive areas, like the rib cage.
Answer: OMG! that's crazy i NEVER EVER heard of anything like that in my life and i would never use it..if you don't have the balls to get a tattoo without taking the pain....you don't need one
Question: Is it illegal to order lidocaine from Canada? Lidocaine is prescription only in the U.S., but I found it online from a canadian pharmacy. Is it illegal to buy it? Will customs confiscate it? What is the penalty for getting caught?
Answer: online canadian pharmacies are just scams. they will not ship to the US, but they might take your money anyway. its the exact same thing as when youre buying some crack and the drug dealer jsut takes your money, its not like youre gonna be able to get the police to help yu
Question: What is the Molecular Weight of Lidocaine Hydrogen Sulfate? Is it the same as crude Lidocaine? Or is it different. Please help Organic Chemistry cannot figure this out!
Question: Can you become allergic to lidocaine all of a sudden? I was just perscribed lidocaine and was allergic to it - well - I felt dizzy, nausous, diarra, just icky. I also have this feeling when I go to the dentist. I have been ok with the dentist until 8 years ago when I passed out in the dentist office. And ever since then I am terrified about going to the dentist because of that. Was that a allergic reaction and can you become allergic to lidocaine and the dentist "caine"?
Had lidocaine in a mouthwash - had to swallow it.
Answer: You can be allergic to just about anything, but you don't describe the usual allergic reaction. The dentist uses the same local anesthetic the doctors do, except their preps usually contain epinephrine as well- to restrict bleeding and extend the effectiveness. Epinephrine is the "fight or flight" chemical your body produces when you are stressed or frightened, and can cause all sorts of odd feelings- including the gut. To find out if you are truly allergic to it you would need to be specifically tested by an allergist. If you suspect you are, that would be a good thing to do, because allergies to medications that are injected can be quite deadly. They can show up all of a sudden, and can go from one mild to one life threatening reaction without warning. And since lidocaine is such a common local anesthetic, you would certainly need to know and have a medicalert tag to the effect. But what I think is you are dealing with an overstressed body in fear of the dentist, and the epinephrine isn't helping matters any. That's what it really sounds like. Still, get tested and find out for certain. Then if it's safe, you can always ask the dentist for a bit of a sedative first, which will help control the other reactions.
Note- you aren't supposed to swallow the mouthwash. You are supposed to swish in in your mouth and spit it out- not swallow it. You feel slighty icky because you just slightly anesthetized your esophogus, stomach and everything else. While it won't hurt you- it's not intended to be swallowed in much quantity.
Question: What's the difference between Aneshtetic Benzocaine, Lidocaine, Prilocaine, and Xylocaine Creams? What's the difference between Aneshtetic Benzocaine, Lidocaine, Prilocaine, and Xylocaine Creams? What is the best way to use this? external use or internal use? I know they are all Numbing Creams or what i mean was a numbing agents. How does these work? Kindly Help Me Guys Please, and I'm looking for a great suppliers, Thanks.
Answer: I think you have to contract a proper suppliers that provides you better suggestion about these products for various wholesale suppliers try http://www.hellotrade.com/changzhou-sunchem-chemical/ suppliers of various creams products and also leading in manufacturing or research in search engines.
Question: Do you feel the effects of a lidocaine injection when you take suboxone? Suboxone is a drug used for opiate addiction and it blocks opiates from receptors (pain receptors) in your brain. I need to have a cyst extracted and need lidocaine to numb the area.
Answer: Lidocaine is not an opiate, it is a locally acting anesthetic which acts on the fast gated sodium channels in the neuron. Basically, it blocks pain signals from the neuron, so it never reaches your brain to be interpreted as pain.
Suboxone acts on a completely different receptor pathway within the brain itself.
Question: How long does lidocaine usually last for? I got stitches last night and the area still feels numb, but i am not sure if it is because it is just bruised or if it is from the lidocaine.
Answer: There are two different kinds of lidocaine, each lasts a different duration.
1) Lidocaine ("Plain")
When injected in or under the skin, prevents sensory nerves from firing by depolarizing sensory nerve axons (the electrical wires of the nerves).
Because plain lidocaine is water soluble, it rapidly flushes away with nearby blood capillaries and veins. The half life for 1 milliliter of plain lidocaine injected below the skin (subcuticular) is about an hour.
2) Lidocaine with epinephrine (LidocaineE)
Works the same as plain lidocaine, except the epinephrine causes all the blood vessels in the area to constrict for hours.
Without blood flow to the area, the lidocaine does not get flushed away.
Depending on the location and the amount injected, LidocaineE can have a half-life up to 6 hours.
If your stitches were placed last night (presumably 24 hours ago), it's not lidocaine causing your numbness.
You probably cut several sensory nerves to the area. Your sensation probably will feel numb for several weeks.
Question: Is it safe and effective to inject lidocaine gel? Hello,
I am putting together a first aid kit for a long trip and was wondering if it is ok to inject lidocaine gel in an emergency. I have a prescription for the gel, but not for an injection. I would be using this in case I needed to suture or staple a wound in an emergency. If not, is it possible to get a lidocaine/epinephrine multi-use vial prescription from my physician? Thanks!
Answer: The short answer is no. Lidocaine gel is not sterile nor is it Pyrogen-free. It contain ingredients that could cause substantial damage in your blood stream, and could cause infections and tissue damage locally, and blood poisoning systemically. Improper dosing (the gel is more concentrated than the injection) can also cause cardiovascular problems.
You may be able to convince your physician to write a prescription for you to use as you describe, but what you are considering is more in the realm of novels or movies reality than real life.
Suturing a wound without proper examination and cleansing could cause more damage than bandaging it until you can get to trained medical help.
Question: I have a syringe and lidocaine, can I numb my own broken tooth? I know they usually use novacaine, but can I use lidocaine and numb my broken tooth? I can't afford a dentist right now and I am in horrible pain!
Answer: Yeah, you can, but I doubt you'd actually numb yourself in the right place...thus screwing up your whole home made tooth extraction. HORRIBLE IDEA.....by the way, where the F did you get the lidocaine?
Question: Is lidocaine as available as cormac mcarthy says it is? So on no country for old men, Javier Bardem blows up a car and strolls into a pharmacy to pick up a few things, one of them being the local anesthetic lidocaine. Can you really get Lidocaine in the injectable form at a pharmacy?
Answer: yes, it's available in several forms.
but he did go behind the counter, not like you can buy it off the shelf.
Question: Can I please have some help with ionic interactions and lidocaine? State which atoms or groups in lidocaine could be involved in its binding to a receptor via an ionic interaction? Give examples of the types of functional group that need to be present in the receptor sites in order for these forms of binding to take place?
Answer: In lidocaine, the amine nitrogen atom (the one furthest from the aromatic ring) is basic and is protonated at normal pH values giving it a positive charge. It therefore interacts with groups in the receptor which have a negative charge. As receptors are proteins, this means you need the receptor active site to contain an amino acid with a sidechain which is acidic (and therefore ionises by losing a proton at normal pH). This limits you to glutamic acid and aspartic acid. You then get an ionic interaction between the positive protonated amine in the lidocaine and the negative deprotonated glutamate (or aspartate) in the receptor.
Question: Can i use lidocaine viscous oral sol on my new cheek/dimple piercings? I just got them pierced an hour ago. My doc prescribed lidocaine for my mouth ulcers. Can I use it to keep my mouth clean and slightly numb?
Answer: it will numb your mouth, but it won't clean, Rinse the inside of your mouth with Biotine every morning, and night, and any time you eat drink or smoke. wash the outsides with anti-bacterial soap.
Question: How effective is a lidocaine/prilocaine topical anesthetic for tattooing? I've found some information on it
not sure how effective it is. Has anyone tried it?
Answer: Well, when i was getting my first tattoo the guy rubbed something on it after he outlined it and i didnt feel a thing after that. I'm not sure if thats what your talking about though, and I COULD TAKE THE PAIN. I didnt even ask for it I'm not too sure why he put it on though...
Question: Why does lidocaine sometimes not work? I've had this problem a couple times at the dentist (different dentists). The dentist will numb the area he is going to work on with lidocaine (or some other ...caine) and the stuff just wont take. He then uses more and it still doesn't work. He then tries another type of anesthetic and it still doesn't work. I either have to suffer through some pain or wait and come back a different day (it worked the next time I came back). I'm only 29, don't smoke, don't do drugs and rarely drink. It this common or could it be something I'm doing that causes it not to work?
Answer: Sometimes the anaesthetic won't take if there is an infection present, or if your nerves aren't exactly where they should be, or even if you're really anxious it can affect the freezing. I don't think it's anything that you did. It just happens. I'll be back. I remember reading about this. I'll see if I can find it. =)
Okay - I found a site that may be able to answer some of your questions. Check this out:
Question: Im allergic to lidocaine. Will that affect me getting an epidural if I need one? When I was younger, I had an allergic reaction to lidocaine. I went to get a filling in my molar and my throat started to like close up and I could breath normally. Now that Im getting closer to my due date, Im getting very nervous about this. I dont plan on getting an epidural, but if I really do need it, I want to know if it would be safe to get it because of my allergic reaction.
Answer: Tell them Now so they can prepare- OK The need to know this - it's possible they can test you -topically to see if there is still a positive reaction or at the least a blood test
They can use a substitue like "sensorcaine" (i have had many epidurals for pain) or xylocaine
Do yourself a favor and INFORM then now ok
Question: I am 22 weeks pregnant and have a question regarding a local anestetic, Lidocaine? I had a "pregnancy tumor" (pyogenic granuloma) growing on my face, so i had it removed, but was injected with lidocaine. Now i am a nervous wreck that i have harmed my unborn baby. Please help, has anyone had this done during pregnancy?
Answer: Oh no you and baby esp. will be just fine!
Its a local, which means it goes no further than the area its injected too.
Question: Do Lidocaine injections in the wrist hurt? I have tendinitis and am getting surgery on Friday and am wanting to know if the injection (Lidocaine) hurts and how much? Just a pinch or like a cortisone shot?
Answer: Have you tried freeing up the tendons in your wrist to free them back up? Here's how to free them up:
With hand resting in front of you with the palm up, bend your wrist as far as you can.. Then press into the area behind the wrist, where they take your pulse, and hold a good amount of pressure on it. After 30 seconds slowly open your wrist up as far as you can, release the pressure but hold your wrist open for another 30 seconds.
For best results relax your body first by taking a deep breath and exhaling then remain this relaxed.
Question: I have aloe with Lidocaine. Can I use it on my dogs allergic rash? She was running through some plants and now has a rash. She's already had her Benadril, given to at the vet, but the rash is itchy. Will the Lidocaine hurt her?
Answer: Benedryl would work better.
Lidocaine Related Products and News
JAMA: The Journal of the American Medical Association
Widely used epidural injections of glucocorticoid plus lidocaine offered little or no benefit over epidural injections of lidocaine alone in treating symptoms of lumbar spinal stenosis, according to findings of a randomized controlled trial of 400 ...
The study involved 62 women with fibromyalgia. Each woman received four injections: two in certain muscles in their shoulders and two more in their buttocks. Some of the women received lidocaine injections, while a "control group" received saline ...
Lidocaine Injections Found to Reduce Hypersensitivity to Pain in Fibromyalgia ...
The drug, if approved, would compete in a market expected to open up with next year's patent expiration of Lidoderm, a lidocaine patch developed and marketed by Endo. Endo (NASDAQ: ENDP), based in Dublin, Ireland, has its U.S. headquarters in Malvern.
Monthly Prescribing Reference
Hospira announced a voluntary recall of one lot of Lidocaine HCl Injection, 2% due to a confirmed customer report of discolored product with visible particles. Particles were detected in the solution and embedded in the molded glass container. The ...
For their double-blind study, published in the European Journal of Pain, investigators administered 100 or 200 mg of lidocaine or saline injections into 62 female FM patients' buttocks and shoulders. The participants were then subjected to mechanical ...
Use of Lidocaine Viscous for teething pain in children can be dangerous: MoH
That changed in 1994, when the anesthetic lidocaine was added; it provides pain relief with no sting. In fact, Bactine now comes with a ?no sting? claim. ? Vicks VapoRub seems like it has been around forever. When was it created? Vicks VapoRub is a ...
AttorneyOne.com, a recognized authority on law, update the website daily regarding all the latest information from the FDA on Lidocaine HCI Injection. The US FDA published on July 30, that one lot of Lidocaine HCI Injection, USP, 2%, 20 mg per mL, 5 mL ...
Linex Legal (press release) (registration)
LOUSY LIDOCAINEPosted on Aug 1, 2014 12:00pm PDT Hospira Announces Voluntary Nationwide Recall Of One Lot Of Lidocaine HCI Injection, USP, 2%, 20 mg per mL Single-dose Vial, Preservative-free, Due To Particulate Matter Hospira, Inc. (NYSE: ...